RXR-β

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Name
Retinoid X receptor β
Symbol
RXR-β
NRNC Symbol
NR2B2

Overview

RXRβ is a member of the nuclear receptor superfamily that mediates signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. Along with other members of the RXR family, RXRβ plays roles in a variety of processes including embryonic patterning and organogenesis, cell proliferation and differentiation. RXRs commonly function as heterodimers with other members of the nuclear receptor superfamily.

Expression

RXR-β is expressed in mulitple organs in many major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, reproductive and cardiopulmonary), with particularly high levels in corpus striatum, pancreas, brown adipose tissue, testis, aorta and skin.

View full NURSA RXR-β expression dataset

Diseases

RXR-β dysfunction has been associated with immune (type I diabetes, psoriasis) and psychiatric (schizophrenia, autism, alcoholism, bipolar disorder and attention deficity hyperactivity disorder (ADHD)) disorders.

Phenotypes

Targeted disruption (knockout) of RXR-β results in defects in the immune system, hearing, homeostasis and metabolism, the liver/biliary system, skin and coat development, the central nervous system (CNS), the reproductive system (spermatogenesis), and also results in prenatal and perinatal lethality. See other isoforms for phenotypes of compound mutants.

View RXR-β Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
HNF4/RXR/TLL/COUP-like receptors
NRNC Group
Retinoic acid X receptors (RXR, USP)

Nomenclature
retinoid acid receptor coregulator-1 (RCoR-1); nuclear receptor subfamily 2, group B, member 2 (NR2B2); retinoid X receptor, β (RXRB); Retinoid X receptor β (RXRβ)

Primary References
Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Näär AM, Kim SY, Boutin JM, Glass CK and Rosenfeld MG (1991) RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67, 1251-66. View Abstract | View PubMed
Fleischhauer K, Park JH, DiSanto JP, Marks M, Ozato K and Yang SY (1992) Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor beta. Nucleic Acids Res 20, 1801. View PubMed
Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A and Evans RM (1992) Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 6, 329-44. View Abstract | View PubMed
Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM and Mader S (1992) Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 68, 377-95. View Abstract | View PubMed

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