Overview

PPARδ is a fatty acid-activated member of the PPAR subfamily of the nuclear receptor superfamily of transcription factors. Collectively the PPAR subfamily plays important roles in lipid and glucose metabolism, and has been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease.

Expression

PPARδ is expressed in most physiological systems including the CNS (central nervous system), endocrine, immune, reproductive, digestive, urinary and cardiopulmonary systems, with particularly high levels in the duodenum, jejunum, ileum, colon and kidney.

View full NURSA PPARδ expression dataset

Diseases

PPARδ dysfunction is associated with colorectal cancer, atherosclerosis, hyperlipidemia, coronary heart disease, defects in body mass, type II diabetes, metabolic syndrome and obesity, as well as Alzheimer's disease.

Phenotypes

Targeted disruption (knockout) of the PPARδ gene results in defects in homeostasis and metabolism, behavioral, neurological and central nervous system (CNS) disruption, defects in embryogenesis and growth and size, adipose tissue, the digestive system, the immune system, the liver and biliary system, tumorigenesis and prenatal & perinatal lethality.

View PPARδ Diseases and Phenotypes section