PPAR-α

Browse nuclear receptors
 
Name
Peroxisome proliferator activated receptor α
Symbol
PPAR-α
NRNC Symbol
NR1C1

Overview

PPARα is a fatty acid-activated member of the PPAR subfamily of the nuclear receptor superfamily of transcription factors. Collectively the PPAR subfamily plays important roles in lipid and glucose metabolism, and has been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease.

Expression

PPARα is expressed primarily in metabolic tissues (brown adipose tissue, liver, kidney) but elevated levels are also present in the digestive (jejunum, ileum, colon, gall bladder) and cardiopulmonary (aorta, heart) systems. 

View full NURSA PPARα expression dataset

Diseases

PPARα dysfunction is associated with susceptibility to hyperapobetalipoproteinemia in addition to a variety of cardiovascular (myocardial infarction, ischemic heart disease, atherosclerosis, hypertension), immune (psoriasis), metabolic (plasma lipid levels, type II daibetes, body mass, plasma triglycerides and cholesterol, liver steatosis and steatohepatitis, hyperlipidemia, obesity, arterial blood pressure) and neurological (Alzheimer's diease) conditions.

Phenotypes

Targeted disruption (knockout) of the PPARα gene is associated with defects in adipose tissue, the cardiovascular system, growth and size, homeostasis and metabolism, the immune system, life span, the liver and biliary system, muscle and skin wound healing.

View PPARα Diseases and Phenotypes section


At a Glance

Phylogeny
Class
TR/RAR/PPAR/VDR-like receptors
NRNC Group
Peroxisome proliferator activated receptors (PPAR)

Nomenclature
nuclear receptor subfamily 1, group C, member 1 (NR1C1); peroxisome proliferative activated receptor, α (PPARA); Peroxisome proliferator activated receptor α (PPARα)

Primary References
Sher T, Yi HF, McBride OW and Gonzalez FJ (1993) cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 32, 5598-604. View Abstract | View PubMed


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