GCNF

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Name
Germ cell nuclear factor 1
Symbol
GCNF
NRNC Symbol
NR6A1

Overview

GCNF is an orphan member of the nuclear receptor superfamily of transcription factors that functions as a transcriptional repressor. It is an essential factor in vertebrate embryogenesis.

Expression

GCNF is expressed at low levels in many tissues but is expressed at high levels in the testes.

View full NURSA GCNF expression dataset

Phenotypes

Disruption (knockout) of GCNF is embryonic lethal and is associated with significant defects in posterior development.

View GCNF Phenotypes section

 


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
GCNF
NRNC Group
Germ cell nuclear factor (GCNF1)

Nomenclature
retinoic acid receptor-related testis-associated receptor (RTR); Germ cell nuclear factor 1 (GCNF1); nuclear receptor subfamily 6, group A, member 1 (NR6A1)

Primary References
Agoulnik IY, Cho Y, Niederberger C, Kieback DG and Cooney AJ (1998) Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF. FEBS Lett 424, 73-8. View Abstract | View PubMed
Kapelle M, Krätzschmar J, Husemann M and Schleuning WD (1997) cDNA cloning of two closely related forms of human germ cell nuclear factor (GCNF). Biochim Biophys Acta 1352, 13-7. View Abstract | View PubMed
Lei W, Hirose T, Zhang LX, Adachi H, Spinella MJ, Dmitrovsky E and Jetten AM (1997) Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation. J Mol Endocrinol 18, 167-76. View Abstract | View PubMed
Chen F, Cooney AJ, Wang Y, Law SW and O'Malley BW (1994) Cloning of a novel orphan receptor (GCNF) expressed during germ cell development. Mol Endocrinol 8, 1434-44. View Abstract | View Mol Endocrinol

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