LRH-1

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Name
Fetoprotein transcription factor
Symbol
LRH-1
NRNC Symbol
NR5A2

Overview

LRH-1 is an orphan member of the nuclear receptor superfamily of transcription factors and a mammalian homolog of the Drosophila fushi tarazu F1 gene product. It is involved in the regulation of genes which participate in steroid, bile acid and cholesterol homeostasis.

Expression

LRH-1 is expressed primarily in the gastrointestinal system (duodenum, jejunum, ileum, colon, gall bladder), liver and ovary.

View full NURSA LRH-1 expression dataset

Phenotypes

Disruption (knockout) of LRH-1 in mice results in compromised intestinal lipid absorption as well as defective embryogenesis and cholesterol homeostasis.

View LRH-1 Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
FTZ-F1/SF1-like receptors
NRNC Group
Fushi tarazu F1-like receptors (SF1, FTF, FTZ-F1)

Nomenclature
CYP7A promoter-binding factor (CPF); fetoprotein-α 1 (AFP) transcription factor (FTF); human B1-binding factor (HB1F); liver receptor homolog 1 (LRH-1); nuclear receptor subfamily 5, group A, member 2 (NR5A2)

Primary References
Nitta M, Ku S, Brown C, Okamoto AY and Shan B (1999) CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene. Proc Natl Acad Sci U S A 96, 6660-5. View Abstract | View PubMed
Li M, Xie YH, Kong YY, Wu X, Zhu L and Wang Y (1998) Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus. J Biol Chem 273, 29022-31. View Abstract | View PubMed

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