NOR1

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Name
Neuron-derived orphan receptor 1
Symbol
NOR1
NRNC Symbol
NR4A3

Overview

NOR1 is a member of the Nur77/NGFI-B subfamily of the nuclear receptor superfamily of transcription factors. Like other Nur77/NGFI-B subfamily members, its expression is induced in response to various stress stimuli and growth factors. NOR-1 has roles in signaling in multiple tissues, including the hypothalamic-pituitary axis.

Expression

NOR1 is expressed at moderate levels in tissues in all major physiological systems (endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural), with peaks of expression in the central nervous system (CNS), specifically the cerebelllum, cerebrum, corpus striatum, olfactory bulb, hypothalamus and pituitary gland, and in the adrenal gland, seminal vesicle, prostate, aorta, heart and skeletal muscle.

View full NURSA NOR1 expression dataset

Phenotypes

Targeted deletion (knockout) of NOR1 results in disruption of embryogenesis, development of the semicircular canals and in acute myeloid leukemia.

View NOR1 Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
NGFIB-like receptors
NRNC Group
Nerve growth factor IB-like receptors (NGFIB, NURR, NOR, HR38, CNR-8)

Nomenclature
chondrosarcoma, extraskeletal myxoid, fused to EWS (CSMF); mitogen induced nuclear orphan receptor (MINOR); translocated in extraskeletal chondrosarcoma (TEC); Neuron-derived orphan receptor 1 (NOR1); nuclear receptor subfamily 4, group A, member 3 (NR4A3)

Primary References
Hedvat CV and Irving SG (1995) The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor. Mol Endocrinol 9, 1692-700. View Abstract | View Mol Endocrinol

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