NURR1

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Name
Nur-related protein 1
Symbol
NURR1
NRNC Symbol
NR4A2

Overview

Nurr1 is a member of the Nur77/NGFI-B subfamily of the nuclear receptor superfamily of transcription factors. Like other Nur77/NGFI-B subfamily members, its expression is induced in response to various stress stimuli and growth factors. Nurr1 has roles in signaling in multiple tissues, including development of dopaminergic neurons.

Expression

Nurr1 is expressed at low to moderate levels in tissues in all major physiological systems (endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural), with peaks of expression in the central nervous system (CNS), specifically the cerebelllum, cerebrum, corpus striatum, olfactory bulb, hypothalamus and pituitary gland, and in the adrenal gland, aorta and brown adipose tissue.

View full NURSA Nurr1 expression dataset

Diseases

Nurr1 dysfunction is associated with susceptibility to Parkinson's Disease and attention deficit hyperactivity disorder.

Phenotypes

Targeted deletion (knockout) of Nurr1 results in disruption of development of dopaminergic neurons.

View Nurr1 Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
NGFIB-like receptors
NRNC Group
Nerve growth factor IB-like receptors (NGFIB, NURR, NOR, HR38, CNR-8)

Nomenclature
Hippocamus zing finger protein 3 (HZF-3); nuclear receptor of T-cells (NOT); regenerating liver nuclear receptor 1 (RNR1); transcriptionally inducible nuclear receptor (TINUR); NGFI-B/nur77 β-type transcription factor homolog (NURR); Nur-related protein 1 (NURR1); nuclear receptor subfamily 4, group A, member 2 (NR4A2)

Primary References
Ichinose H, Ohye T, Suzuki T, Sumi-Ichinose C, Nomura T, Hagino Y and Nagatsu T (1999) Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs. Gene 230, 233-9. View Abstract | View PubMed
Mages HW, Rilke O, Bravo R, Senger G and Kroczek RA (1994) NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3. Mol Endocrinol 8, 1583-91. View Abstract | View Mol Endocrinol
Law SW, Conneely OM, DeMayo FJ and O'Malley BW (1992) Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol 6, 2129-35. View Abstract | View Mol Endocrinol

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