Nur77

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Name
growth factor-inducible immediate early gene nur/77-like receptor
Symbol
Nur77
NRNC Symbol
NR4A1

Overview

Nur77 is a growth factor-inducible member of the Nur77/NGFI-B subfamily of the nuclear receptor superfamily of transcription factors. Like other Nurr77/NGFI-B subfamily members, its expression is induced in response to various stress stimuli and growth factors. Nur77 is involved in mediating apoptotic signaling in thymocytes and tumor cells, and plays a role in signaling in the hypothalamic-pituitary axis.

Expression

Nur77 is expressed at low to moderate levels in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural), with peaks of expression in the aorta, adrenal gland, olfactory bulb, testes, lung and skeletal muscle.

View full NURSA Nur77 expression dataset

Phenotypes

Targeted deletion (knockout) of Nur77 results in disruption of behavior & neurological function, the immune system, the liver and biliary system, as well as in tumorigenesis.

View Nur77 Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
NGFIB-like receptors
NRNC Group
Nerve growth factor IB-like receptors (NGFIB, NURR, NOR, HR38, CNR-8)

Nomenclature
orphan nuclear receptor T3 (TR3); growth factor-inducible protein 1 (GFRP1); growth factor-inducible nuclear protein N10 (NP10); steroid receptor TR3 (TR3); orphan nuclear receptor HMR (HMR); growth factor-inducible immediate early gene nur/77 (NUR77); early response protein NAK1 (NAK1); Nerve growth factor IB-like receptor (NGFIB); nuclear receptor subfamily 4, group A, member 1 (NR4A1)

Primary References
Chang C, Kokontis J, Liao SS and Chang Y (1989) Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily. J Steroid Biochem 34, 391-5. View Abstract | View PubMed
Nakai A, Kartha S, Sakurai A, Toback FG and DeGroot LJ (1990) A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. Mol Endocrinol 4, 1438-43. View Abstract | View Mol Endocrinol

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