PR

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Name
Progesterone receptor
Symbol
PR
NRNC Symbol
NR3C3

Overview

The progesterone receptor (PR) is a progestin-activated steroid receptor member of the nuclear receptor superfamily of transcription factors. It plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Expression

PR is expressed at trace to low levels in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural), with peaks in the uterus and overy, cerebellum, spinal cord and hypothalamus.

View full NURSA PR expression dataset

Diseases

PR dysfunction has been associated with cancer (ovarian cancer, breast cancer, endometrial cancer, prostate cancer), metabolic disorders (progesterone resistance, obesity, osteoporosis), cardiovascular defects (aortic aneurysm), neurological defects (migraine, vertigo) and reproductive conditions (endometriosis, infertility).

Phenotypes

Targeted deletion (knockout) of PR results in developmental, behavioral, reproductive and immune system phenotypes.

View PR Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
Steroid receptors
NRNC Group
Glucocorticoid-like receptors (AR, GR, MR, PR)

Nomenclature
nuclear receptor subfamily 3, group C, member 3 (NR3C3); progesterone receptor (PGR); Progesterone receptor (PR)

Primary References
Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F and Milgrom E (1987) Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA. Biochem Biophys Res Commun 143, 740-8. View Abstract | View PubMed
Conneely OM, Sullivan WP, Toft DO, Birnbaumer M, Cook RG, Maxwell BL, Zarucki-Schulz T, Greene GL, Schrader WT and O'Malley BW (1986) Molecular cloning of the chicken progesterone receptor. Science 233, 767-70. View Abstract | View PubMed
Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H and Chambon P (1990) Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 9, 1603-14. View Abstract | View PubMed

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