Overview

The MR is a mineralocorticoid and glucocorticoid-activated steroid receptor member of the nuclear receptor superfamily of transcription factors. It plays a critical role in regulating electrolyte and fluid balance in the kidney, as well as having specific roles in the central nervous system (CNS).

Expression

MR is expressed at moderate levels in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the brain stem, cerebellum, colon, prostate and skin.

View full NURSA MR expression dataset

Diseases

MR dysfunction has been associated with metabolic disorders (pseudohypoaldosteronism), cardiovascular defects (hypertension), psychiatric disorders (depression, stress) and reproductive conditions (preeclampsia).

Phenotypes

Targeted deletion (knockout) of MR results in pseudohypoaldosteronism, hyperkalemia, hyponatremia and a strong increase in plasma concentrations of renin, angiotenisin II and aldosterone. Death occurs from dehydration through sodium and water loss. Floxed deletion of MR in the limbic system results in impaired behavioral plasticity.

View MR Diseases and Phenotypes section