ERR-γ

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Name
Estrogen-related receptor γ
Symbol
ERR-γ
NRNC Symbol
NR3B3

Overview

ERR-γ is a member of the ERR orphan subfamily of the nuclear receptor superfamily of transcription factors. While it is structurally homologous to estrogen receptors and binds estrogen response elements, it is not activated by estrogens.

Expression

While it is expressed in most major physiological systems at low to moderate levels (endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural), ERRγ is predominantly expressed in the central nervous system (CNS), notably in the brain stem, cerebellum, corpus striatum, olfactory bulb, spinal cord, hypothalamus and pituitary gland.

View full NURSA ERRγ expression dataset

Phenotypes

Targeted deletion (knockout) of ERRγ results in lactatemia, electrocardiographic abnormalities, and death during the first week of life.

View ERRγ Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
Steroid receptors
NRNC Group
Estrogen-related receptors (ERR)

Nomenclature
estrogen-related receptor 3 (ERR3); nuclear receptor subfamily 3, group B, member 3 (NR3B3); estrogen-related receptor γ (ESRRG); Estrogen-related receptor γ (ERRγ)

Primary References
Heard DJ, Norby PL, Holloway J and Vissing H (2000) Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult. Mol Endocrinol 14, 382-92. View Abstract | View Mol Endocrinol
Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q and Caskey CT (1999) Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR. Gene 228, 101-9. View Abstract | View PubMed
Eudy JD, Yao S, Weston MD, Ma-Edmonds M, Talmadge CB, Cheng JJ, Kimberling WJ and Sumegi J (1998) Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41. Genomics 50, 382-4. View PubMed

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