ERR-β

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Name
Estrogen-related receptor β
Symbol
ERR-β
NRNC Symbol
NR3B2

Overview

ERR-β is a member of the ERR orphan subfamily of the nuclear receptor superfamily of transcription factors. While it is structurally homologous to estrogen receptors and binds estrogen response elements, it is not activated by estrogens. It has a role in early placental development.

Expression

ERRβ is expressed at low to moderate levels in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with peaks in the eye, kidney, thyroid gland, testis and heart.

View full NURSA ERRβ expression dataset

Diseases

ERRβ dysfunction has been associated with deafness.

Phenotypes

Targeted deletion (knockout) of ERRβ results in placental defects and prenatal lethality. Deletion of ERRβ in specific cell types in the inner ear results in defective production of endolymph.

View ERRβ Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
Steroid receptors
NRNC Group
Estrogen-related receptors (ERR)

Nomenclature
estrogen receptor-like 2 (ESRL2); nuclear receptor subfamily 3, group B, member 2 (NR3B2); estrogen-related receptor β (ESRRB); Estrogen-related receptor β (ERRβ)

Primary References
Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q and Caskey CT (1999) Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR. Gene 228, 101-9. View Abstract | View PubMed
Giguère V, Yang N, Segui P and Evans RM (1988) Identification of a new class of steroid hormone receptors. Nature 331, 91-4. View Abstract | View PubMed

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