ERR-α

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Name
Estrogen-related receptor α
Symbol
ERR-α
NRNC Symbol
NR3B1

Overview

ERR-α is a member of the ERR orphan subfamily of the nuclear receptor superfamily of transcription factors. While it is structurally homologous to estrogen receptors and binds estrogen response elements, it is not activated by estrogens. It functions as a metabolic regulator by modulating the expression of enzymes involved in adipogenesis, energy metabolism, and lipid, eicosanoid, and steroid synthesis.

Expression

ERRα is expressed robustly in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the olfactory bulb, jejunum, ileum, kidney, brown adipose tissue, heart and skeletal muscle.

View full NURSA ERRα expression dataset

Diseases

ERRα dysfunction has been associated with bone density and type II diabetes.

Phenotypes

Targeted deletion (knockout) of ERRα results in defects in reduced fat mass.

View ERRα Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
Steroid receptors
NRNC Group
Estrogen-related receptors (ERR)

Nomenclature
estrogen receptor-like 1 (ESRL1); nuclear receptor subfamily 3, group B, member 1 (NR3B1); estrogen-related receptor α (ESRRA); Estrogen-related receptor α (ERRα)

Primary References
Giguère V, Yang N, Segui P and Evans RM (1988) Identification of a new class of steroid hormone receptors. Nature 331, 91-4. View Abstract | View PubMed

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