EAR2

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Name
V-erbA related protein
Symbol
EAR2
NRNC Symbol
NR2F6

Overview

EAR2 is a member of the COUP-TF orphan subfamily of the nuclear receptor superfamily of transcription factors. Its functions include negative regulation of renin gene transcription and neuronal development.

Expression

EAR2 is expressed in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the colon, gall bladder, kidney and aorta.

View full NURSA EAR2 expression dataset

Phenotypes

Targeted disruption (knockout) of the Ear2 in mice results in abnormal development of the locus coeruleus, which also impairs the functionality of the forebrain clock and affects nociception.

View EAR2 Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
HNF4/RXR/TLL/COUP-like receptors
NRNC Group
COUP-TF-like receptors (COUP-TF, SVP, EAR2)

Nomenclature
ERBA-related gene-2 (EAR-2); v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2 (ERBAL2); Chicken ovalbumin upstream promoter transcription factor III (COUP-TFIII); nuclear receptor subfamily 2, group F, member 6 (NR2F6); V-erbA related protein (EAR2)

Primary References
Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K and Yamamoto T (1988) Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. Nucleic Acids Res 16, 11057-74. View Abstract | View PubMed

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