COUP-TFII

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Name
Chicken ovalbumin upstream promoter transcription factor II
Symbol
COUP-TFII
NRNC Symbol
NR2F2

Overview

COUP-TFII is a member of the COUP-TF orphan subfamily of the nuclear receptor superfamily of transcription factors. It has roles in angiogenesis, vascular remodeling and heart development.

Expression

COUP-TFII is expressed in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the adrenal gland, kidney, ovary, uterus and vas deferens.

View full NURSA COUP-TFII expression dataset

Phenotypes

Targeted deletion (knockout) of COUP-TFII results in defects in insulin secretion and insulin sensitivity, radial and anterior patterning in the stomach, angiogenesis and heart development.

View COUP-TFII Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
HNF4/RXR/TLL/COUP-like receptors
NRNC Group
COUP-TF-like receptors (COUP-TF, SVP, EAR2)

Nomenclature
apolipoprotein regulatory protein 1 (ARP1); ADP-ribosylation factor related protein 1 ( ); transcription factor COUP2 (TFCOUP2); nuclear receptor subfamily 2, group F, member 2 (NR2F2); Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII)

Primary References
Ladias JA and Karathanasis SK (1991) Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science 251, 561-5. View Abstract | View PubMed
Wang LH, Ing NH, Tsai SY, O'Malley BW and Tsai MJ (1991) The COUP-TFs compose a family of functionally related transcription factors. Gene Expr 1, 207-16. View Abstract | View PubMed

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