PNR

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Name
Photoreceptor-specific nuclear receptor
Symbol
PNR
NRNC Symbol
NR2E3

Overview

PNR is an orphan member of the nuclear receptor superfamily of transcription factors that plays a role in retinal photoreceptor cell differentiation and degeneration.

Expression

PNR is expressed exclusively in the eye.

View full NURSA PNR expression dataset

Diseases

PNR dysfunction has been associated with enhanced S-cone syndrome and retinitis pigmentosa-37.

Phenotypes

A spontaneous mutation of the PNR allele results in retinal degeneration.

View PNR Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
HNF4/RXR/TLL/COUP-like receptors
NRNC Group
Tailless-like receptors (TLL, TLX, PNR, DSF, FAX)

Nomenclature
retina-specific nuclear receptor (RNR); nuclear receptor subfamily 2, group E, member 3 (NR2E3); Photoreceptor-specific nuclear receptor (PNR)

Primary References
Chen F, Figueroa DJ, Marmorstein AD, Zhang Q, Petrukhin K, Caskey CT and Austin CP (1999) Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells. Proc Natl Acad Sci U S A 96, 15149-54. View Abstract | View PubMed
Kobayashi M, Takezawa S, Hara K, Yu RT, Umesono Y, Agata K, Taniwaki M, Yasuda K and Umesono K (1999) Identification of a photoreceptor cell-specific nuclear receptor. Proc Natl Acad Sci U S A 96, 4814-9. View Abstract | View PubMed

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