Overview

Testicular orphan receptor 4 (TR4) is a member of the nuclear receptor superfamily of transcription factors. TR4 is thought to function as a transcriptional modulator of NR target genes.

Expression

TR4 is expressed in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the cerebrum, kidney, thymus and testis.

View full NURSA TR4 expression dataset

Phenotypes

Targeted disruption (knockout) of TR4 results in delayed and disrupted late meiotic prophase in spermatogenesis.

View TR4 Diseases and Phenotypes section

Nuclear Receptor Pages User Guide (updated Oct 2008)

	At a Glance
	Phylogeny Class HNF4/RXR/TLL/COUP-like receptors NRNC Group Orphan nuclear receptors TR2, TR4 Nomenclature transforming growth factor β activated kinase1 (TAK1); nuclear receptor subfamily 2, group C, member 2 (NR2C2); testicular orphan receptor 4 (TR4) Primary References Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S and Burbach JP (1994) Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. Proc Natl Acad Sci U S A 91, 6040-4. View Abstract \| View PubMed	At a Glance Orthologs Datasets Reagents Interactions Transcriptomics and Cistromics Diseases and Phenotypes Ligands Molecular Endocrinology Literature

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Overview

Expression

Phenotypes

At a Glance

At a Glance

Orthologs

Datasets

Reagents

Interactions

Transcriptomics and Cistromics

Diseases and Phenotypes

Ligands

Molecular Endocrinology

Literature