Overview

Members of the testicular orphan receptor subfamily of the nuclear receptors, TR2 and TR4, function as negative modulators to suppress the transcriptional activity of other members of the nuclear receptor superfamily such as AR function in prostate, ERα in the mammary gland or PPARα in keratinocytes.

Expression

TR2 is expressed in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the testis.

View full NURSA TR2 expression dataset

Nuclear Receptor Pages User Guide (updated Oct 2008)

	At a Glance
	Phylogeny Class HNF4/RXR/TLL/COUP-like receptors NRNC Group Orphan nuclear receptors TR2, TR4 Nomenclature nuclear receptor subfamily 2, group C, member 1 (NR2C1); testicular orphan receptor 2 (TR2) Primary References Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H and Chang Y (1989) Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains. Biochem Biophys Res Commun 165, 735-41. View Abstract \| View PubMed	At a Glance Orthologs Datasets Reagents Interactions Transcriptomics and Cistromics Diseases and Phenotypes Ligands Molecular Endocrinology Literature

My NURSA

Molecule Navigator

Receptors

Coregulators

Ligands

Select a range

1-E F-L M-Q R-Z

Select a specific molecule

Feedback

Questions? Comments?
Send Feedback Here

Overview

Expression

At a Glance

At a Glance

Orthologs

Datasets

Reagents

Interactions

Transcriptomics and Cistromics

Diseases and Phenotypes

Ligands

Molecular Endocrinology

Literature