Overview

RXRγ is a member of the nuclear receptor superfamily that mediates signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. Along with other members of the RXR family, RXRγ plays roles in a variety of processes including embryonic patterning and organogenesis, cell proliferation and differentiation. RXRs commonly function as heterodimers with other members of the nuclear receptor superfamily.

Expression

RXRγ is expressed in multiple organs in many physiological systems with peaks in the central nervous system (CNS; eye, brain stem, cerebrum, corpus striatum, olfactory bulb, spinal cord, hypothalamus and pituitary gland), endocrine system (principally thyroid gland), metabolic tissues (liver, brown adipose tissue and white adipose tissue), immune system (spleen, thymus), reproductive system (prostate, testis, vas deferens), cardiovascular system (heart), and in bone, skeletal muscle and skin.

View full NURSA RXRγ expression dataset

Diseases

RXR-γ dysfunction has been associated with metabolic (type II diabetes) and psychiatric (schizophrenia, autism, alcoholism, bipolar disorder and attention deficity hyperactivity disorder (ADHD)) disorders.

Phenotypes

Targeted disruption (knockout) of RXR-γ results in impaired development or activation of cholinergic neurones in nigrostriatal extrapyramidal pathways. 

View RXRγ Diseases and Phenotypes section