HNF4-γ

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Name
Hepatocyte nuclear factor 4 receptor γ
Symbol
HNF4-γ
NRNC Symbol
NR2A2

Overview

HNF4γ is a member of the HNF4 orphan subfamily of the nuclear receptor superfamily. It has been shown to constitutively bind fatty acids.

Expression

HNF4γ is almost exclusively expressed in the gastrointestinal system (duodenum, jejunum, ileum, colon), liver and kidney, with lower levels in the gall bladder, kidney, skin, central nervous system (CNS) and endocrine system (adrenal gland, thyroid and pancreas).

View full NURSA HNF4γ expression dataset

Phenotypes

Targeted disruption (knockout) of HNF4γ results in defects in behavior, homeostasis and metabolism, and growth and development.

View HNF4γ Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
HNF4/RXR/TLL/COUP-like receptors
NRNC Group
Hepatocyte nuclear factor 4 (HNF4)

Nomenclature
nuclear receptor subfamily 2, group A, member 2 (NR2A2); hepatocyte nuclear factor 4, γ (HNF4G); Hepatocyte nuclear factor 4 receptor γ (HNF4γ)

Primary References
Plengvidhya N, Antonellis A, Wogan LT, Poleev A, Borgschulze M, Warram JH, Ryffel GU, Krolewski AS and Doria A (1999) Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. Diabetes 48, 2099-102. View Abstract | View PubMed
Drewes T, Senkel S, Holewa B and Ryffel GU (1996) Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. Mol Cell Biol 16, 925-31. View Abstract | View PubMed

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