Overview

The CAR orphan subfamily of the nuclear receptor superfamily of transcription factors consists of CAR (in the human) and CAR-β (only in the mouse). CARs play roles in regulating expression of CYP genes in response to exogenous xenobiotics and endogenous lipid compounds.

Expression

CAR is almost exclusively expressed in the gastrointestinal system (stomach, duodenum, jejunum, ileum, colon, gall bladder) and liver, with lower levels in the seminal vesicle and eye.

View full NURSA CAR expression dataset

Nuclear Receptor Pages User Guide (updated Oct 2008)

	At a Glance
	Phylogeny Class TR/RAR/PPAR/VDR-like receptors NRNC Group Vitamin D3-like receptors (VDR, PXR, CAR) Nomenclature orphan nuclear receptor MB67 (MB67); nuclear receptor subfamily 1, group I, member 3 (NR1I3); Constitutive androstane receptor 1 (CAR1) Primary References Choi HS, Chung M, Tzameli I, Simha D, Lee YK, Seol W and Moore DD (1997) Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. J Biol Chem 272, 23565-71. View Abstract \| View PubMed Baes M, Gulick T, Choi HS, Martinoli MG, Simha D and Moore DD (1994) A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol Cell Biol 14, 1544-52. View Abstract \| View PubMed	At a Glance Orthologs Datasets Reagents Interactions Transcriptomics and Cistromics Diseases and Phenotypes Ligands Molecular Endocrinology Literature

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Overview

Expression

At a Glance

At a Glance

Orthologs

Datasets

Reagents

Interactions

Transcriptomics and Cistromics

Diseases and Phenotypes

Ligands

Molecular Endocrinology

Literature