PXR

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Name
Pregnane X receptor
Symbol
PXR
NRNC Symbol
NR1I2

Overview

PXR is a xenobiotic-activated member of the nuclear receptor superfamily of transcription factors. PXR is involved in transcriptional induction of hepatic xenobiotic-catabolizing cytochrome 3A enzymes, playing a fundamental role in protecting body tissues from toxic bile acids.

Expression

PXR is almost exlcusively expressed in the gastrointestinal system (stomach, duodenum, jejunum, ileum, colon and gall bladder) and liver, with lower levels in the kidney and ovary.

View full NURSA PXR expression dataset

Diseases

PXR dysfunction is associated with immune disorders (sclerosing cholangitis, inflammatory bowel disease) and biliary primary cirrhosis

View PXR Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
TR/RAR/PPAR/VDR-like receptors
NRNC Group
Vitamin D3-like receptors (VDR, PXR, CAR)

Nomenclature
steroid and xenobiotic receptor (SXR); pregnane-activated receptor (PAR); benzoate X receptor (BXR); nuclear receptor subfamily 1, group I, member 2 (NR1I2); Pregnane X receptor (PXR)

Primary References
Blumberg B, Sabbagh W, Juguilon H, Bolado J, van Meter CM, Ong ES and Evans RM (1998) SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 12, 3195-205. View Abstract | View PubMed
Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Bäckman M, Ohlsson R, Postlind H, Blomquist P and Berkenstam A (1998) Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A 95, 12208-13. View Abstract | View PubMed
Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterström RH, Perlmann T and Lehmann JM (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92, 73-82. View Abstract | View PubMed

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