FXR-α

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Name
Farnesoid receptor α
Symbol
FXR-α
NRNC Symbol
NR1H4

Overview

Bile acids are important for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. FXRα is a bile acid-activated member of the nuclear receptor superfamily of transcription factors.

Expression

FXRα is expressed primarily in the duodenum, jejunum, ileum, colon, gall bladder, liver and kidney.

View full NURSA FXRα expression dataset

Phenotypes

Targeted disruption of FXRα results in elevated serum bile acids, cholesterol and triglycerides, increased hepatic cholesterol and triglycerides, a proatherogenic serum lipoprotein profile and reduced bile acid pools fecal bile acid excretion.

View FXRα Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
TR/RAR/PPAR/VDR-like receptors
NRNC Group
Ecdysone-like receptors (EcR, LXR, FXR)

Nomenclature
retinoid X receptor-interacting protein 14 (RIP14); bile acid receptor (BAR); farnesoid X-activated receptor (FXR); farnesol receptor HRR-1 (HRR-1); nuclear receptor subfamily 1, group H, member 4 (NR1H4); Farnesoid receptor α (FXRα)

Primary References
Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ and Shan B (1999) Identification of a nuclear receptor for bile acids. Science 284, 1362-5. View Abstract | View PubMed

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