LXR-α

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Name
Oxysterol receptor α
Symbol
LXR-α
NRNC Symbol
NR1H3

Overview

LXR-α is an oxysterol-activated member of the LXR subfamily of the nuclear receptor superfamily of transcription factors. It has been suggested to be the major sensor of dietary cholesterol.

Expression

LXR-α is expressed at low to moderate levels in most physiological systems, including the central nervous system (CNS), endocrine system, gastrointestinal system, reproductive system, cardiopulmonary system, skeletal muscle and skin. Primary sites of expression are in the gall bladder, liver, kidney, jejunum, duodenum, brown adipose tissue and white adipose tissue.

View full NURSA LXRα expression dataset

Diseases

LXR-α variants are associated with cholelithiasis and modified plasma lipid profile.

Phenotypes

LXR-α deficienty results in impaired cholesterol and bile acid metabolism in mice.

View LXR-α Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
TR/RAR/PPAR/VDR-like receptors
NRNC Group
Ecdysone-like receptors (EcR, LXR, FXR)

Nomenclature
liver X receptor, α (LXRA); nuclear receptor subfamily 1, group H, member 3 (NR1H3); Oxysterol receptor α (LXRα)

Primary References
Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA and Mangelsdorf DJ (1995) LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev 9, 1033-45. View Abstract | View PubMed

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