LXR-β

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Name
Oxysterol receptor β
Symbol
LXR-β
NRNC Symbol
NR1H2

Overview

LXR-β is an oxysterol-activated member of the LXR subfamily of the nuclear receptor superfamily of transcription factors. LXRβ is involved in regulation of cholesterol homeostasis in the liver.

Expression

LXR-β is expressed at moderate to high levels in most physiological systems, including the central nervous system (CNS), endocrine system, gastrointestinal system, reproductive system, cardiopulmonary system, skeletal muscle and skin. Peaks of expression are in the cerebellum, corpus striatum, olfactory bulb and pituitary gland, the thyroid, kidney, testis and aorta.

View full NURSA LXR-β expression dataset

Phenotypes

Targeted disruption (knockout) of the LXR-β gene is associated with defects in the cardiovascular system, homeostasis and metabolism and the nervous system.

View LXR-β Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
TR/RAR/PPAR/VDR-like receptors
NRNC Group
Ecdysone-like receptors (EcR, LXR, FXR)

Nomenclature
retinoid X receptor-interacting protein 15 (RIP15); nuclear receptor subfamily 1, group H, member 2 (NR1H2); liver X receptor β (LXRB); steroid hormone-nuclear receptor NER (NER); ubiquitously-expressed nuclear receptor (UNR); Oxysterol receptor β (LXRβ)

Primary References
Song C, Kokontis JM, Hiipakka RA and Liao S (1994) Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors. Proc Natl Acad Sci U S A 91, 10809-13. View Abstract | View PubMed
Shinar DM, Endo N, Rutledge SJ, Vogel R, Rodan GA and Schmidt A (1994) NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. Gene 147, 273-6. View Abstract | View PubMed

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