ROR-γ

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Name
RAR-related orphan receptor γ
Symbol
ROR-γ
NRNC Symbol
NR1F3

Overview

ROR-γ is a member of the orphan ROR subfamily of the nuclear receptor superfamily of transcription factors, with a role in thymocyte development and homeostasis.

Expression

ROR-γ is expressed at low to moderate levels in most physiological systems, including the central nervous system (CNS), endocrine system, gastrointestinal system, reproductive system, cardiopulmonary system, skeletal muscle and skin. Peaks of expression are seen in the gastrointestinal system (jejunum, ileum, colon), metabolic tissues (liver, kidney) and immune system (thymus gland).

View full NURSA ROR-γ expression dataset

Phenotypes

Targeted disruption (knockout) of ROR-γ is associated with defects in lymphoid organogenesis and in homeostasis and metabolism.

View ROR-γ Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
TR/RAR/PPAR/VDR-like receptors
NRNC Group
RAR-related orphan receptors (ROR, HR3)

Nomenclature
nuclear receptor subfamily 1, group F, member 3 (NR1F3); RAR-related orphan receptor C (RORC); thymus orphan receptor (TOR); nuclear receptor RZR-γ (RZRC); retinoic acid receptor-related orphan receptor γ (RORC); RAR-related orphan receptor γ (RORγ)

Primary References
Ortiz MA, Piedrafita FJ, Pfahl M and Maki R (1995) TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals. Mol Endocrinol 9, 1679-91. View Abstract | View Mol Endocrinol
Hirose T, Smith RJ and Jetten AM (1994) ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. Biochem Biophys Res Commun 205, 1976-83. View Abstract | View PubMed

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