ROR-β

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Name
RAR-related orphan receptor β
Symbol
ROR-β
NRNC Symbol
NR1F2

Overview

ROR-β is a member of the orphan ROR subfamily of the nuclear receptor superfamily of transcription factors which, along with ROR-α, appears to have a general role in cell survival in the central nervous system.

Expression

With few exceptions (including the uterus and vas deferens), ROR-β is exclusively expressed in the central nervous system (CNS), principally the cerebrum, corpus striatum, spinal cord, eye, hypothalamus and spinal cord.

View full NURSA ROR-β expression dataset

Phenotypes

Targeted disruption (knockout) of ROR-β is associated with central nervous system (CNS) defects in behavior and neurological function, compromised growth and development, and retinal degneration.

View ROR-β Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
TR/RAR/PPAR/VDR-like receptors
NRNC Group
RAR-related orphan receptors (ROR, HR3)

Nomenclature
nuclear receptor subfamily 1, group F, member 2 (NR1F2); RAR-related orphan receptor B (RORB); nuclear receptor RZR-β (RZRB); retinoic acid receptor-related orphan receptor β (RORB); RAR-related orphan receptor β (RORβ)

Primary References
Carlberg C, Hooft van Huijsduijnen R, Staple JK, DeLamarter JF and Becker-André M (1994) RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Mol Endocrinol 8, 757-70. View Abstract | View Mol Endocrinol

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