REV-ERB-α

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Name
Rev-Erb α
Symbol
REV-ERB-α
NRNC Symbol
NR1D1

Overview

RevErb-α, along with RevErb-β, is a member of the orphan RevErb subfamily of the nuclear receptor superfamily of transcription factors. Both members of this family are widely expressed during development and adult life, indicating broad roles in cell proliferation and physiology.

Expression

RevErb-α is expressed at low to moderate levels in most physiological systems, including the central nervous system (CNS), endocrine system, gastrointestinal system, reproductive system, cardiopulmonary system and metabolic tissues, with elevated expression in testis and skeletal muscle.

View full NURSA RevErb-α expression dataset

Phenotypes

Targeted disruption of the RevErbA-α gene leads to defects in cerebellar development and control of the circadian cycle.

View RevErbA-α Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
TR/RAR/PPAR/VDR-like receptors
NRNC Group
Rev-Erb (NRD, E75)

Nomenclature
nuclear receptor subfamily 1, group D, member 1 (NR1D1); thyroid hormone receptor, α-like (THRAL); ERBA-related 1 (EAR1); orphan nuclear receptor NR1D1 (ONR1D1); Rev-Erb α (REVERBa)

Primary References
Lazar MA, Hodin RA, Darling DS and Chin WW (1989) A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Mol Cell Biol 9, 1128-36. View Abstract | View PubMed
Miyajima N, Horiuchi R, Shibuya Y, Fukushige S, Matsubara K, Toyoshima K and Yamamoto T (1989) Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell 57, 31-9. View Abstract | View PubMed

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