Overview

RAR-γ is a member of the nuclear receptor superfamily of transcription factors that mediates signaling by all-trans and 9-cis retinoic acid, hormones derived from vitamin A (retinol). Along with other members of the RAR family, RAR-γ is redundantly involved in vertebrates in the pleiotropic control of embryonic patterning and organogenesis, cell proliferation, differentiation, apoptosis and homeostatic control in multiple physiological systems.

Expression

RAR-γ is expressed in mulitple organs in many major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, reproductive and cardiopulmonary), with particularly high levels in the eye, pituitary gland, adrenal gland, tongue, colon, brown adipose tissue, white adipose tissue, ovary, uterus, preputial gland, prostate, vas deferens, aorta, heart, lung and skin.

View full NURSA RARγ expression dataset

Diseases

RARγ dysfunction has been shown to be associated with schizophrenia and other psychiatric conditions.

Phenotypes

Targeted disruption (knockout) of the RARγ gene in mice is associated with defects in: homeostasis and metabolism; eye development and vision; embryogenesis; hearing; endocrine/exocrine gland function, growth and size; the cardiovascular system; the reproductive system; the digestive system; the immune system; prenatal and perinatal lethality; craniofacial and limb, digit, skin, coat and nail development; muscular and skeletal function; the renal and urinary system; and the respiratory system. It also results in prenatal and perinatal lethality.

View RARγ Diseases and Phenotypes section