Overview

TRβ and its family member TRα are endocrine nuclear receptors that mediate the transcriptional effects of thyroid hormone (triiodothyronine, T3). They play critical roles in the differentiation, growth. metabolism and physiology of a wide variety of tissues.

Expression

TRβ is widely expressed in many physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, reproductive and cardiopulmonary) with particularly high levels in the cerebrum, hypothalamus, pituitary gland, kidney, brown adipose tissues, preputial gland and heart.

View full NURSA TRβ expression dataset

Diseases

TRβ dysfunction is assiciated with generalized resistance to thyroid hormone (RTH) in addition to Grave's disease, and psychological traits such as low intelligence. 

Phenotypes

Targeted disruption (knockout) of the TRβ gene in mice is associated with defects in: the central nervous system (CNS); homeostasis and metabolism; hearing; endocrine/exocrine gland function, growth and size; the cardiovascular system; craniofacial and limb & digit development; muscular function; and the respiratory system. It is also associated with tumorigenesis. 

View TRβ Diseases and Phenotypes section