TR-α

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Name
Thyroid hormone receptor α
Symbol
TR-α
NRNC Symbol
NR1A1

Overview

TRα and its family member TRβ, are endocrine nuclear receptors that mediate the transcriptional effects of thyroid hormone (triiodothyronine, T3). They play critical roles in the differentiation, growth. metabolism and physiology of a wide variety of tissues. Alternatively spliced transcript variants encode TRα isoforms with partially distinct biological functions.

Expression

TRα is widely expressed in many physiological systems (endocrine, metabolic, gastrointestinal, reproductive and cardiopulmonary) with particularly high levels in the central nervous system (CNS), including the brain stem, cerebellum, corpus striatum, olfactory bulb and hypothalamus.

View full NURSA TRα expression dataset

Diseases

TRα dysfunction is assiciated with pituitary adenomas and thyroid cancer.

Phenotypes

Targeted disruption (knockout) of the TRα gene in mice is associated with a wide variety of defects - behavioral/neurological, in the cardiovascular system, in growth and size, in homeostasis and metabolism, postnatal lethality, in the cardiovascular, immune, nervous and reproductive systems, and with skeletal, vision and eye defects.

View TRα Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
TR/RAR/PPAR/VDR-like receptors
NRNC Group
Thyroid hormone receptors (TR)

Nomenclature
(EAR7); nuclear receptor subfamily 1, group A, member 1 (NR1A1); thyroid hormone receptor, α (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) (THRA); erythroblastic leukemia viral (v-erb-a) oncogene homolog 1, avian (ERBA1); avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 (c-erbA-1); Thyroid hormone receptor α (TRα)

Primary References
Benbrook D and Pfahl M (1987) A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library. Science 238, 788-91. View Abstract | View PubMed
Sap J, Muñoz A, Damm K, Goldberg Y, Ghysdael J, Leutz A, Beug H and Vennström B (1986) The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature 324, 635-40. View Abstract | View PubMed
Miyajima N, Horiuchi R, Shibuya Y, Fukushige S, Matsubara K, Toyoshima K and Yamamoto T (1989) Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell 57, 31-9. View Abstract | View PubMed

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