SHP

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Name
Small heterodimeric partner
Symbol
SHP
NRNC Symbol
NR0B2

Overview

SHP is an atypical member of the nuclear receptor superfamily of transcription factors; consisting of a putative ligand-binding domain but lacking a conventional DNA-binding domain. SHP has been suggested to play a role in repression of nuclear receptor signaling by heterodimerization with other members of the superfamily.

Expression

SHP is expressed prrimarily in endocrine organs (adrenal, pancreas), gastrointestinal organs (stomach, duodenum, ileum, colon and gall bladder), metabolic organs (liver, kidney), reproductive organs (ovary and testis), cardiopulmonary organs (heart and lung), and CNS (cerebrum).

Diseases

SHP dysfunction is associated with mild early-onset obesity, birthweight adiposity and early-onset type 2 diabetes.

View full NURSA SHP expression dataset

Phenotypes

Disruption (knockout) of the SHP gene in mice is associated with defects in the liver and biliary system, homeostasis, metabolism and germ cell meiosis.

View SHP Diseases and Phenotypes section


 Nuclear Receptor Pages User Guide (updated Oct 2008)

At a Glance
Phylogeny
Class
Domain-depleted receptors
NRNC Group
DAX-like receptors (DAX, SHP)

Nomenclature
nuclear receptor subfamily 0, group B, member 2 (NR0B2); short heterodimer partner (shp); Small heterodimeric partner (SHP)

Primary References
Seol W, Choi HS and Moore DD (1996) An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science 272, 1336-9. View Abstract | View PubMed

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