Dihydrotestosterone

521-18-6

10635

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Dihydrotestosterone is the primary physiological ligand for the androgen receptor (AR), a steroid receptor member of the nuclear receptor superfamily of transcription factors. The precursor, testosterone, itself a weaker AR agonist, is secreted by the Leydig cells of the testes and converted to dihydrotestosterone in the prostate by 5α-reductase. It plays important roles in normal prostate growth and in the development of prostate cancer.