SMRT

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Name
Silencing mediator of retinoid and thyroid receptors
Symbol
SMRT

Overview

The nuclear receptor corepressor SMRT is a broad specificity corepressor for many members of the nuclear receptor superfamily, in addition to numerous other classes of transcriptional factors.

Expression

SMRT is broadly expressed in a variety of tissues, with particularly high levels in the central nervous system (olfactory bulb, cerebellum, hypothalamus), reproductive systems (testis, uterus, ovary), aorta, thymus and white adipose tissue.
View the NURSA coregulator expression profiling dataset

Interactions New!

View the NURSA SMRT HeLa cell protein interaction network in the pane below

Diseases

SMRT has been shown to be upregulated in malignant endometrium.

Phenotypes

Null deletion of SMRT is embryonic lethal due to a heart defect. Targeted deletion of SMRT demonstrated its critical role in forebrain development and in the maintenance of the neural stem cell fate.  

View the NURSA SMRT Diseases and Phenotypes section in the pane below


At a Glance

Nomenclature
Silencing mediator of retinoid and thyroid receptors (SMRT); Thyroid-, retinoic-acid-receptor-associated co-repressor (TRAC2); Nuclear receptor co-repressor 2 (NCoR2)

Primary References
Sande S and Privalsky ML (1996) Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. Mol Endocrinol 10, 813-25. View Abstract | View Mol Endocrinol

Chen JD and Evans RM (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377, 454-7. View Abstract | View PubMed


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