Overview

The nuclear receptor corepressor SMRT is a broad specificity corepressor for many members of the nuclear receptor superfamily, in addition to numerous other classes of transcriptional factors.

Expression

SMRT is broadly expressed in a variety of tissues, with particularly high levels in the central nervous system (olfactory bulb, cerebellum, hypothalamus), reproductive systems (testis, uterus, ovary), aorta, thymus and white adipose tissue.
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Interactions New!

View the NURSA SMRT HeLa cell protein interaction network in the pane below

Diseases

SMRT has been shown to be upregulated in malignant endometrium.

Phenotypes

Null deletion of SMRT is embryonic lethal due to a heart defect. Targeted deletion of SMRT demonstrated its critical role in forebrain development and in the maintenance of the neural stem cell fate.

View the NURSA SMRT Diseases and Phenotypes section in the pane below

	At a Glance
	Nomenclature Silencing mediator of retinoid and thyroid receptors (SMRT); Thyroid-, retinoic-acid-receptor-associated co-repressor (TRAC2); Nuclear receptor co-repressor 2 (NCoR2) Primary References Sande S and Privalsky ML (1996) Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. Mol Endocrinol 10, 813-25. View Abstract \| View Mol Endocrinol Chen JD and Evans RM (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377, 454-7. View Abstract \| View PubMed	At a Glance Orthologs Datasets Interactions Transcriptomics and Cistromics Diseases and Phenotypes Molecular Endocrinology Literature

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	A message from the NURSA co-directors: To the nuclear receptor and coregulator scientific community, On behalf of its members, we would like to extend to you a warm welcome to the Nuclear Receptor Signaling Atlas (NURSA), a trans-NIH consortium organized in August 2002 and currently in its second phase (2007-2012) supported by the NIDDK, the NHLBI, and the NIEHS. Read more

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