Activating signal cointegrator-2
ASC-2 is a broad-specificity coactivator that mediates transcriptional activation by nuclear receptors as well as other transcription factors.
ASC-2 is broadly expressed in a variety of tissues, with peaks of expression in the central nervous system (cerebrum, corpus striatum, olfactory bulb) and reproductive system (ovary, vas deferens) in addition to the thymus and kidney.
Mutations in ASC-2 have been demonstrated in breast cancer.
Homozygous null deletion of ASC-2 results in defective placentation, embryonic lethality and, in heterozygote null mutants, retarded growth and postnatal mortality.