Browse coregulators
Activating signal cointegrator-2


ASC-2 is a broad-specificity coactivator that mediates transcriptional activation by nuclear receptors as well as other transcription factors.


ASC-2 is broadly expressed in a variety of tissues, with peaks of expression in the central nervous system (cerebrum, corpus striatum, olfactory bulb) and reproductive system (ovary, vas deferens) in addition to the thymus and kidney.
View the NURSA coregulator expression profiling dataset

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View the NURSA ASC-2 HeLa cell protein interaction network in the pane below


Mutations in ASC-2 have been demonstrated in breast cancer.


Homozygous null deletion of ASC-2 results in defective placentation, embryonic lethality and, in heterozygote null mutants, retarded growth and postnatal mortality.

View the NURSA ASC-2 Diseases and Phenotypes section in the pane below 

At a Glance

Activating signal cointegrator-2 (ASC-2); Nuclear receptor coactivator (NRC); Peroxisome proliferator-activated receptor (PPAR)-interacting protein (PRIP); Nuclear receptor-activating protein, 250 kDa (RAP250); Thyroid hormone receptor-binding protein (TRBP); Nuclear receptor coactivator 6 (NCOA6); Amplified in breast cancer-3 protein (AIB3)

Primary References
Mahajan MA and Samuels HH (2000) A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. Mol Cell Biol 20, 5048-63. View Abstract | View PubMed

Ko L, Cardona GR and Chin WW (2000) Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc Natl Acad Sci U S A 97, 6212-7. View Abstract | View PubMed

Zhu Y, Kan L, Qi C, Kanwar YS, Yeldandi AV, Rao MS and Reddy JK (2000) Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J Biol Chem 275, 13510-6. View Abstract | View PubMed

Caira F, Antonson P, Pelto-Huikko M, Treuter E and Gustafsson JA (2000) Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J Biol Chem 275, 5308-17. View Abstract | View PubMed

Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS and Lee JW (1999) A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. J Biol Chem 274, 34283-93. View Abstract | View PubMed

Guan XY, Meltzer PS, Dalton WS and Trent JM (1994) Identification of cryptic sites of DNA sequence amplification in human breast cancer by chromosome microdissection. Nat Genet 8, 155-61. View Abstract | View PubMed

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