Overview

ARA70 was initially identified as the product of a gene fused to the RET proto-oncogene in thyroid papillary carcinoma. It was subsequently shown to be required for efficient transcriptional activation by the androgen receptor (AR) a member of the nuclear receptor superfamily of transcription factors.

Expression

ARA70 is broadly expressed in a variety of tissues, with elevated expression in metabolic tissues (white and brown adipose tissue, kidney), the gastrointestinal system (duodenum, jejenum) as well as the male reproductive system (testis and prostate).
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Interactions New!

View the NURSA ARA70 HeLa cell protein interaction network in the pane below

Diseases

Dysregulation of ARA70 expression has been documented in polycystic ovarian syndrome and in prostate cancer.

View the NURSA ARA70 Diseases section in the pane below

	At a Glance
	Nomenclature AR-associated protein 70 (ARA70); RET-fused gene (RFG); Ret-activating protein ELE1 (ELE1); RET-activating gene ELE1 (PTC3); Nuclear receptor coactivator 4 (NCOA4) Primary References Gao T, Brantley K, Bolu E and McPhaul MJ (1999) RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays. Mol Endocrinol 13, 1645-56. View Abstract \| View Mol Endocrinol Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W and Peeters B (1999) Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform. Mol Endocrinol 13, 117-28. View Abstract \| View Mol Endocrinol Yeh S and Chang C (1996) Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc Natl Acad Sci U S A 93, 5517-21. View Abstract \| View PubMed Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G and Fusco A (1994) Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma. Oncogene 9, 509-16. View Abstract \| View PubMed Bongarzone I, Butti MG, Coronelli S, Borrello MG, Santoro M, Mondellini P, Pilotti S, Fusco A, Della Porta G and Pierotti MA (1994) Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas. Cancer Res 54, 2979-85. View Abstract \| View PubMed	At a Glance Orthologs Datasets Interactions Transcriptomics and Cistromics Diseases and Phenotypes Molecular Endocrinology Literature

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	A message from the NURSA co-directors: To the nuclear receptor and coregulator scientific community, On behalf of its members, we would like to extend to you a warm welcome to the Nuclear Receptor Signaling Atlas (NURSA), a trans-NIH consortium organized in August 2002 and currently in its second phase (2007-2012) supported by the NIDDK, the NHLBI, and the NIEHS. Read more

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