Overview

AIB1/SRC-3 is a broad-specificity transcriptional coregulator which mediates the activating functions of nuclear receptors and other transcription factors. First cloned in the mouse as the p300 and CBP interacting protein p/CIP, it was the third member of the SRC/p160 coregulator family to be characterized.

Expression

AIB1/SRC-3 is widely expressed in a variety of tissues in myriad physiological systems, with peaks of expression in the thymus, kidney, aorta, spleen, testis and lungs.

View the NURSA coregulator expression profiling dataset

Interactions New!

View the NURSA AIB1/SRC-3 HeLa cell protein interaction network in the pane below.

Diseases

AIB1/SRC-3 overexpression has been implicated in breast and ovarian cancer, in addition to cancers of the prostate, endometrium, liver and pancreas.

Phenotypes

SRC-3 has been shown by null deletion in mice to be required for normal growth, puberty, female reproductive function and mammary gland development.

View the NURSA AIB1/SRC-3 Diseases and Phenotypes section in the pane below

	Interactions
	NURSA NCBI Receptors AR COUP-TFI ER-α ER-β ERR-α ERR-β LRH-1 GR HNF4-γ LXR-α LXR-β PPAR-α PPAR-γ PXR PR ROR-β RAR-α RAR-β RAR-γ RXR-α RXR-β SHP TR-α TR-β VDR Nur77 Coregulators REG-γ AIB1 ANCO-1 BAF57 BRCA1 CBP CARM1 Cyclin D1 p300 TFIIB GRIP1 LMP2 MMS19 NCoR p68 p72 PIN1 PRMT1 PIAS1 SMAD3 SUMO-1 SMRT Sirt1 SRA SRC-1 TBP 14-3-3 eta P/CAF RelA Others ABL1 BMP6 BMP7 CHUK MAPK14 E2F1 ERBB2 ETS1 ETS2 ETV1 FOS GSK3B IKBKB JUN SMAD2 MYC NPAS2 MAPK1 TRIM21 STAT6 NKX2-1 UBC HIST3H3 IKBKG EBAG9 YWHAQ Ptpn6 Ikbkg Lgals3 Mef2c Per1 Sap18 Tbx4 Sufu ATAD2 Rnf19a SUFU Prdx5 Sirt2 Zfp219 Polr3f Ercc8 Gtf2e1 Lass2 Trps1 Setdb1 Ehmt2 Tle6 HIST4H4 tat AW146020	At a Glance Orthologs Datasets Interactions Transcriptomics and Cistromics Diseases and Phenotypes Molecular Endocrinology Literature

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	A message from the NURSA co-directors: To the nuclear receptor and coregulator scientific community, On behalf of its members, we would like to extend to you a warm welcome to the Nuclear Receptor Signaling Atlas (NURSA), a trans-NIH consortium organized in August 2002 and currently in its second phase (2007-2012) supported by the NIDDK, the NHLBI, and the NIEHS. Read more

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