AIB1

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Name
Amplified in breast cancer 1
Symbol
AIB1

Overview

AIB1/SRC-3 is a broad-specificity transcriptional coregulator which mediates the activating functions of nuclear receptors and other transcription factors. First cloned in the mouse as the p300 and CBP interacting protein p/CIP, it was the third member of the SRC/p160 coregulator family to be characterized.

Expression

AIB1/SRC-3 is widely expressed in a variety of tissues in myriad physiological systems, with peaks of expression in the thymus, kidney, aorta, spleen, testis and lungs.

View the NURSA coregulator expression profiling dataset

Interactions New!

View the NURSA AIB1/SRC-3 HeLa cell protein interaction network in the pane below.

Diseases

AIB1/SRC-3 overexpression has been implicated in breast and ovarian cancer, in addition to cancers of the prostate, endometrium, liver and pancreas.

Phenotypes

SRC-3 has been shown by null deletion in mice to be required for normal growth, puberty, female reproductive function and mammary gland development.

View the NURSA AIB1/SRC-3 Diseases and Phenotypes section in the pane below


At a Glance

Nomenclature
Activator of thyroid hormone receptor (ACTR); Amplified in breast cancer 1 (AIB1); p300/CBP-interacting protein (p/CIP); Receptor-associated coactivator 3 (RAC3); Steroid receptor coactivator 3 (SRC-3); Thyroid hormone receptor activator molecule 1 (TRAM-1); Nuclear receptor coactivator 3 (NCOA3)

Primary References
Suen CS, Berrodin TJ, Mastroeni R, Cheskis BJ, Lyttle CR and Frail DE (1998) A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity. J Biol Chem 273, 27645-53. View Abstract | View PubMed

Takeshita A, Cardona GR, Koibuchi N, Suen CS and Chin WW (1997) TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J Biol Chem 272, 27629-34. View Abstract | View PubMed

Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y and Evans RM (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90, 569-80. View Abstract | View PubMed

Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM and Meltzer PS (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277, 965-8. View Abstract | View PubMed

Li H, Gomes PJ and Chen JD (1997) RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc Natl Acad Sci U S A 94, 8479-84. View Abstract | View PubMed

Torchia J, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK and Rosenfeld MG (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387, 677-84. View Abstract | View PubMed

Guan XY, Xu J, Anzick SL, Zhang H, Trent JM and Meltzer PS (1996) Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer. Cancer Res 56, 3446-50. View Abstract | View PubMed


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