AIB1

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Name
Amplified in breast cancer 1
Symbol
AIB1

AIB1 is a broad-specificity transcriptional coregulator which mediates the activating functions of nuclear receptors and other transcription factors. First cloned in the mouse as p/CIP, it was the third member of the SRC/p160 coregulator family to be characterized.


 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Activator of thyroid hormone receptor (ACTR); Amplified in breast cancer 1 (AIB1); p300/CBP-interacting protein (p/CIP); Receptor-associated coactivator 3 (RAC3); Steroid receptor coactivator 3 (SRC-3); Thyroid hormone receptor activator molecule 1 (TRAM-1); Nuclear receptor coactivator 3 (NCOA3)

Primary References
Suen CS, Berrodin TJ, Mastroeni R, Cheskis BJ, Lyttle CR and Frail DE (1998) A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity. J Biol Chem 273, 27645-53. View Abstract | View PubMed
Takeshita A, Cardona GR, Koibuchi N, Suen CS and Chin WW (1997) TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J Biol Chem 272, 27629-34. View Abstract | View PubMed
Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y and Evans RM (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90, 569-80. View Abstract | View PubMed
Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM and Meltzer PS (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277, 965-8. View Abstract | View PubMed
Li H, Gomes PJ and Chen JD (1997) RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc Natl Acad Sci U S A 94, 8479-84. View Abstract | View PubMed
Torchia J, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK and Rosenfeld MG (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387, 677-84. View Abstract | View PubMed
Guan XY, Xu J, Anzick SL, Zhang H, Trent JM and Meltzer PS (1996) Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer. Cancer Res 56, 3446-50. View Abstract | View PubMed

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