GRIP1

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Name
Glucocorticoid receptor interacting protein 1
Symbol
GRIP1
GRIP1 is a transcriptional coregulator which mediates the activating functions of members of nuclear receptor superfamily. It was the second member of the SRC/p160 coactivator family to be characterized.

 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Glucocorticoid receptor interacting protein 1 (GRIP1); Transcriptional intermediary factor 2 (TIF2); Nuclear receptor coactivator 2 (NCOA2)

Primary References
Hong H, Kohli K, Garabedian MJ and Stallcup MR (1997) GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol Cell Biol 17, 2735-44. View Abstract | View PubMed
Voegel JJ, Heine MJ, Zechel C, Chambon P and Gronemeyer H (1996) TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J 15, 3667-75. View Abstract | View PubMed
Hong H, Kohli K, Trivedi A, Johnson DL and Stallcup MR (1996) GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci U S A 93, 4948-52. View Abstract | View PubMed

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