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Glucocorticoid receptor interacting protein 1


GRIP1/TIF2 is a transcriptional coregulator which mediates the activating functions of members of nuclear receptor superfamily. It was the second member of the SRC/p160 coactivator family to be characterized.


GRIP1/TIF2 is broadly expressed in a variety of tissues, with particularly high levels in the testis, central nervous system (cerebrum, olfactory bulb, corpus striatum), kidney, ovary and uterus.
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View the NURSA GRIP1/SRC-2 HeLa cell protein interaction network in the pane below


GRIP1/TIF2 overexpression has been documented in breast cancer and endometrial cancer. Fusions of the TIF2 gene with that encoding MOZ, a member of the MYST family of acetyltransferases, have also been demonstrated in acute myeloid leukemia.


Loss of SRC-2 expression results in compromised fertility in males due to defects in spermatogenesis and adhesion of Sertoli cells to germ cells, and in females due to placental hypoplasia.

View the NURSA GRIP1/TIF2 Diseases and Phenotypes section in the pane below


At a Glance

Glucocorticoid receptor interacting protein 1 (GRIP1); Transcriptional intermediary factor 2 (TIF2); Nuclear receptor coactivator 2 (NCOA2)

Primary References
Hong H, Kohli K, Garabedian MJ and Stallcup MR (1997) GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol Cell Biol 17, 2735-44. View Abstract | View PubMed

Voegel JJ, Heine MJ, Zechel C, Chambon P and Gronemeyer H (1996) TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J 15, 3667-75. View Abstract | View PubMed

Hong H, Kohli K, Trivedi A, Johnson DL and Stallcup MR (1996) GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci U S A 93, 4948-52. View Abstract | View PubMed

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