Overview

GRIP1/TIF2 is a transcriptional coregulator which mediates the activating functions of members of nuclear receptor superfamily. It was the second member of the SRC/p160 coactivator family to be characterized.

Expression

GRIP1/TIF2 is broadly expressed in a variety of tissues, with particularly high levels in the testis, central nervous system (cerebrum, olfactory bulb, corpus striatum), kidney, ovary and uterus.
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Diseases

GRIP1/TIF2 overexpression has been documented in breast cancer and endometrial cancer. Fusions of the TIF2 gene with that encoding MOZ, a member of the MYST family of acetyltransferases, have also been demonstrated in acute myeloid leukemia.

Phenotypes

Loss of SRC-2 expression results in compromised fertility in males due to defects in spermatogenesis and adhesion of Sertoli cells to germ cells, and in females due to placental hypoplasia.

View the NURSA GRIP1/TIF2 Diseases and Phenotypes section in the pane below

	At a Glance
	Nomenclature Glucocorticoid receptor interacting protein 1 (GRIP1); Transcriptional intermediary factor 2 (TIF2); Nuclear receptor coactivator 2 (NCOA2) Primary References Hong H, Kohli K, Garabedian MJ and Stallcup MR (1997) GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol Cell Biol 17, 2735-44. View Abstract \| View PubMed Voegel JJ, Heine MJ, Zechel C, Chambon P and Gronemeyer H (1996) TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J 15, 3667-75. View Abstract \| View PubMed Hong H, Kohli K, Trivedi A, Johnson DL and Stallcup MR (1996) GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci U S A 93, 4948-52. View Abstract \| View PubMed	At a Glance Orthologs Datasets Interactions Transcriptomics and Cistromics Diseases and Phenotypes Molecular Endocrinology Literature

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