SRC-1

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Name
Steroid receptor coactivator 1
Symbol
SRC-1

Overview

SRC-1 is a transcriptional coregulator which mediates the activating functions of members of nuclear receptor superfamily. SRC-1 is the prototypical member of the SRC/p160 coactivator family.

Expression

SRC-1 is broadly expressed in a variety of tissues, with particularly high levels in several areas of the brain (cerebrum, corpus striatum, cerebellum, hypothalamus) in addition to the thymus, testis, pituitary and white adipose tissue.
View the NURSA coregulator expression profiling dataset

Interactions New!

View the NURSA SRC-1 HeLa cell protein interaction network in the pane below

Diseases

SRC-1 overexpression has been documented in breast cancer, endometrial cancer and prostate cancer.

Phenotypes

Loss of SRC-1 expression results in defects in skeletal and reproductive function, in addition to dysfunction in other physiological systems.

View the NURSA SRC-1 Diseases and Phenotypes section in the pane below

 


At a Glance

Nomenclature
Steroid receptor coactivator 1 (SRC-1); Nuclear receptor coactivator 1 (NCOA1)

Primary References
Oñate SA, Tsai SY, Tsai MJ and O'Malley BW (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270, 1354-7. View Abstract | View PubMed


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