SHARP

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Name
SMRT/HDAC1 associated repressor protein
Symbol
SHARP

Overview

SHARP was originally identified as an interacting protein for the Msx-2 transcription factor. It is a steroid-inducible coregulator that was originally shown to act as a corepressor of members of the retinoic acid receptor (RAR) subfamily of nuclear receptors. It interacts with SMRT and SRA, as well as members of the NURD histone deacetylase complex.

Expression

SHARP is expressed primarily in the central nervous system (brain), the metabolic system (kidney), the immune system (thymus, spleen) and the reproductive system (testis).

PubMed

Disease

SHARP has been shown to be overexpressed in colon and ovarian cancer.

Phenotypes

Targeted deletion (knockout) of SHARP in mice suggests a crucial role in early development, particularly in the immune system, with other phenotypes in the cardiovascular, digestive, endocrine and metabolic systems.

View SHARP Diseases and Phenotypes section


 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
spen homolog, transcriptional regulator (Drosophila) (SPEN); SMRT/HDAC1 associated repressor protein (SHARP); Msx2-interacting protein (MINT)

Primary References
Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M and Evans RM (2001) Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. Genes Dev 15, 1140-51. View Abstract | View PubMed
Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE and Maxson R (1997) Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA. Mech Dev 65, 3-17. View Abstract | View PubMed

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