p300

Browse coregulators
 
Name
E1A binding protein p300
Symbol
p300

Overview

p300 and its closely related protein CBP are transcriptional cointegrators which mediate the functions of multiple transcription factors, including members of the nuclear receptor superfamily, in a wide variety of developmental and physiological processes.

Interactions New!

View the NURSA p300 HeLa cell protein interaction network in the pane below

Diseases

Dysregulation of p300 expression or function has been demonstrated in leukemia and various other cancers, in addition to Rubinstein-Taybi syndrome.

Phenotypes

Null deletion of p300 results in defects in myriad developmental and physiological defects , including the immune system, hematopoiesis, myogenesis and the cardiovascular system.

View the NURSA p300 Diseases and Phenotypes section in the pane below 


At a Glance

Nomenclature
E1A binding protein p300 (p300)

Primary References
Chakravarti D, LaMorte VJ, Nelson MC, Nakajima T, Schulman IG, Juguilon H, Montminy M and Evans RM (1996) Role of CBP/P300 in nuclear receptor signalling. Nature 383, 99-103. View Abstract | View PubMed

Eckner R, Ewen ME, Newsome D, Gerdes M, DeCaprio JA, Lawrence JB and Livingston DM (1994) Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev 8, 869-84. View Abstract | View PubMed


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