CBP

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Name
CREB-binding protein
Symbol
CBP

Overview

CBP and its closely related protein p300 are transcriptional cointegrators which mediate the functions of multiple transcription factors, including members of the nuclear receptor superfamily, in a wide variety of developmental and physiological processes.

Expression

CBP is broadly expressed in a variety of tissues, with peaks of expression in the central nervous system (cerebrum, corpus striatum, cerebellum, brain stem, hypothalamus) and reproductive system (testis, ovary, uterus) in addition to the thymus and kidney.
View the NURSA coregulator expression profiling dataset

Interactions New!

View the NURSA CBP HeLa cell protein interaction network in the pane below

Diseases

Dysregulation of CBP expression or function has been demonstrated in Huntington's Disease, leukemia and Rubinstein-Taybi syndrome.

Phenotypes

Null deletion of CBP results in defects in myriad physiological systems, including the immune system, hematopoiesis, skeletal function, mental retardation and other developmental defects.

View the NURSA CBP Diseases and Phenotypes section in the pane below


At a Glance

Nomenclature
CREB-binding protein (CBP); CREB binding protein (Rubinstein-Taybi syndrome) (CREBBP)

Primary References
Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK and Rosenfeld MG (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85, 403-14. View Abstract | View PubMed

Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR and Goodman RH (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-9. View Abstract | View PubMed


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