CARM1

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Name
Coactivator-associated arginine methyltransferase-1
Symbol
CARM1

Overview

CARM1 is an arginine methyltransferase which targets transcriptional coactivators, including SRC-1 and CBP, to regulate transcription at their cognate promoters. It has been shown to function as a coregulator for several members of the nuclear receptor superfamily.

Expression

CARM1 is broadly expressed in a variety of tissues, with peaks of expression in the central nervous system (corpus striatum, olfactory bulb, hypothalamus, pituitary), reproductive system (ovary, testis) and metabolic tissues (muscle, thyroid, aorta).
View the NURSA coregulator expression profiling dataset

Interactions New!

View the NURSA CARM1 HeLa cell protein interaction network in the pane below

Diseases

CARM1 has been shown to be overexpressed in prostate cancer and maps to a genomic location influencing circulating levels of homocysteine and therefore susceptibility to vascular diseases.

Phenotypes

Homozygous null deletion of CARM1 results in perinatal mortality and defects in protein methylation.

View the NURSA CARM1 Diseases and Phenotypes section in the pane below 


At a Glance

Nomenclature
Coactivator-associated arginine methyltransferase-1 (CARM1); Protein arginine N-methyltransferase 4 (PRMT4)

Primary References
Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW and Stallcup MR (1999) Regulation of transcription by a protein methyltransferase. Science 284, 2174-7. View Abstract | View PubMed


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