TDG

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Name
Thymine-DNA glycosylase
Symbol
TDG
T:G mismatch-specific thymine DNA glycosylase catalyzes base excision repair of deaminated methylcytosine. It was shown to be a coregulator through its potentiation of estrogen receptor α (ER-α) activity.

 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
thymine-DNA glycosylase (TDG)

Primary References
Chen D, Lucey MJ, Phoenix F, Lopez-Garcia J, Hart SM, Losson R, Buluwela L, Coombes RC, Chambon P, Schär P and Ali S (2003) T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. J Biol Chem 278, 38586-92. View Abstract | View PubMed
Neddermann P, Gallinari P, Lettieri T, Schmid D, Truong O, Hsuan JJ, Wiebauer K and Jiricny J (1996) Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. J Biol Chem 271, 12767-74. View Abstract | View PubMed

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