Overview

PGC-1β is a protein related to the cold-inducible coactivator PGC-1 α, and has been shown to coactivate several members of the nuclear receptor superfamily of transcription factors. Like PGC1-α, it is highly expressed in brown fat and heart and induced in the liver during fasting, indicating a potential role in hepatic gluconeogenesis.

Expression

PGC-1β is detectable at elevated levels in heart and skeletal muscle, with lower levels in brain, kidney, liver, adrenal gland, ovary, intestine, and white adipose tissue. PubMed

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View the NURSA PGC-1β HeLa cell protein interaction network in the pane below

Diseases

Dysregulation of the PGC-1β gene has been associated with metabolic disorders and cancer.

Phenotypes

PGC-1β has been shown by null deletion in mice to be required for normal growth, puberty, female reproductive function and mammary gland development.

View the NURSA PERC1 Diseases and Phenotypes section in the pane below

	At a Glance
	Nomenclature PPAR-γ coactivator 1 β (PGC-1β); Peroxisome proliferator-activated receptor γ coactivator (PERC); Peroxisome proliferative activated receptor, γ, coactivator 1, β (PPARGC1B) Primary References Kressler D, Schreiber SN, Knutti D and Kralli A (2002) The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J Biol Chem 277, 13918-25. View Abstract \| View PubMed Lin J, Puigserver P, Donovan J, Tarr P and Spiegelman BM (2002) Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem 277, 1645-8. View Abstract \| View PubMed	At a Glance Orthologs Datasets Interactions Transcriptomics and Cistromics Diseases and Phenotypes Molecular Endocrinology Literature

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	A message from the NURSA co-directors: To the nuclear receptor and coregulator scientific community, On behalf of its members, we would like to extend to you a warm welcome to the Nuclear Receptor Signaling Atlas (NURSA), a trans-NIH consortium organized in August 2002 and currently in its second phase (2007-2012) supported by the NIDDK, the NHLBI, and the NIEHS. Read more

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