TIF1-β

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Name
Tripartite motif-containing 28
Symbol
TIF1-β

TIF1 β is a member of a subgroup of RING (really interesting new gene) finger proteins containing a RING finger, two B box-type fingers and a putative coiled-coil domain (RBCC domain). It has been shown to enhance glucocorticoid receptor (GR) regulation of target gene expression.


At a Glance

Nomenclature
Krab associated protein 1 (KAP-1); Tripartite motif-containing 28 (TRIM28); Ttripartite motif-containing 28 (TIF1β)

Primary References
Underhill C, Qutob MS, Yee SP and Torchia J (2000) A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. J Biol Chem 275, 40463-70. View Abstract | View PubMed

Chang CJ, Chen YL and Lee SC (1998) Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression. Mol Cell Biol 18, 5880-7. View Abstract | View PubMed

Le Douarin B, Nielsen AL, Garnier JM, Ichinose H, Jeanmougin F, Losson R and Chambon P (1996) A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J 15, 6701-15. View Abstract | View PubMed


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