TIF1-α

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Name
Transcriptional intermediary factor 1
Symbol
TIF1-α

TIF1-α was cloned as the prototypical member of the TIF1 family of corepressors, characterized by possession of a RBCC motif and a C-terminal bromodomain preceded by a PHD finger, in addition to binding sites for the KRAB silencing domains of C2H2 zinc finger domains. The TIF1-gene product was independently characterized as the powerfull coactivator CARM1 C-terminal coactivator partner (CCCP), which binds to the C-terminal region of CARM1 and cooperates synergistically with CARM1 to enhance NR function.


At a Glance

Nomenclature
CARM1 C-terminal coactivator partner (CCCP); Transcriptional intermediary factor 1 (TIF1α)

Primary References
Thénot S, Bonnet S, Boulahtouf A, Margeat E, Royer CA, Borgna JL and Cavaillès V (1999) Effect of ligand and DNA binding on the interaction between human transcription intermediary factor 1alpha and estrogen receptors. Mol Endocrinol 13, 2137-50. View Abstract | View Mol Endocrinol

Thénot S, Henriquet C, Rochefort H and Cavaillès V (1997) Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. J Biol Chem 272, 12062-8. View Abstract | View PubMed


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