PGC-1

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Name
PPARγ coactivator 1
Symbol
PGC-1

Overview

Originally cloned as PGC-1, PGC-1α is a cold-inducible protein, highly expressed in brown fat, that was initially shown to enhance the activity of the nuclear receptors PPAR-γ and TR on the uncoupling protein -1 promoter, and was subsequently shown to coactivate other members of the nuclear receptor superfamily. Studies have indicated a role for PGC1-α in hepatic gluconeogenesis.

Expression

PGC-1 is expressed in a variety of tissues, principally metabolic tissues (heart, kidney, brown adipose tissue, muscle) and the central nervous system (olfactory bulb, cerebrum, hypothalamus).
View the NURSA coregulator expression profiling dataset

Diseases

Variants of PGC-1 have been characterized in diabetes, diabetic retinopathy, hypertension and metabolic syndrome.

Phenotypes

Null deletion of PGC-1 results in defects in adaptive energy metabolism, muscle dysfunction, abnormal weight control and hepatic steatosis.  

View the NURSA PGC-1 Diseases and Phenotypes section in the pane below


At a Glance

Nomenclature
PPAR γ coactivator 1 (PGC-1); Peroxisome proliferative activated receptor γ coactivator 1 (PPARGC1A)

Primary References
Esterbauer H, Oberkofler H, Krempler F and Patsch W (1999) Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics 62, 98-102. View Abstract | View PubMed

Puigserver P, Wu Z, Park CW, Graves R, Wright M and Spiegelman BM (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-39. View Abstract | View PubMed


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