NURSA | PGC-1 - PPAR γ coactivator 1

PGC-1

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PELP1

PGC-1β

Name

PPAR γ coactivator 1

Symbol

PGC-1

Originally cloned as PGC-1, PGC-1α is a cold-inducible protein, highly expressed in brown fat, that was initially shown to enhance the activity of PPAR-γ and TR on the uncoupling protein -1 promoter, and was subsequently shown to coactivate other nuclear receptors. Studies have indicated a role for PGC1-α in hepatic gluconeogenesis.

Coregulator Pages User Guide (updated Oct 2008)

	At a Glance
	Nomenclature PPAR γ coactivator 1 (PGC-1); Peroxisome proliferative activated receptor γ coactivator 1 (PPARGC1A) Primary References Esterbauer H, Oberkofler H, Krempler F and Patsch W (1999) Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics 62, 98-102. View Abstract \| View PubMed Puigserver P, Wu Z, Park CW, Graves R, Wright M and Spiegelman BM (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-39. View Abstract \| View PubMed	At a Glance Orthologs Datasets Interactions Transcriptomics and Cistromics Diseases and Phenotypes Molecular Endocrinology Literature

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At a Glance

At a Glance

Orthologs

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Interactions

Transcriptomics and Cistromics

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Molecular Endocrinology

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