TRAP220

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Name
Thyroid receptor-associated proteincomplex 220 kDa component
Symbol
TRAP220
Originally isolated as PBP, a PPAR-γ binding protein, TRAP220 is a nuclear receptor interaction subunit of the broad spectrum DRIP/TRAP coregulator complex, which mediates transcriptional activation by members of the nuclear receptor superfamily and other transcription factors. This subunit has been individually characterized as a nuclear receptor coactivator.

 Coregulator Pages User Guide (updated Oct 2008)

At a Glance
Nomenclature
Vitamin D receptor interacting protein 205 kDa (DRIP205); Activator-recruited cofactor complex 205 kDa component (ARC205); PPAR binding protein (PBP); Thyroid receptor-associated proteincomplex 220 kDa component (TRAP220); Thyroid receptor-interacting protein 2 (TRIP2); PPAR binding protein (PPARBP)

Primary References
Wang Q, Sharma D, Ren Y and Fondell JD (2002) A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. J Biol Chem 277, 42852-8. View Abstract | View PubMed

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